FIRST-IN-HUMAN STUDY OF THE SAFETY, PHARMACOKINETICS, AND PHARMACODYNAMICS OF FIRST-IN-CLASS FATTY ACID SYNTHASE INHIBITOR TVB-2640 ALONE AND WITH A TAXANE IN ADVANCED TUMORS

Background: We conducted a first-in-human dose-escalation study with the oral FASN inhibitor TVB-2640 to determine the maximum tolerated dose (MTD) and recommended phase 2 dose (RP2D), as monotherapy and with a taxane.Methods: This completed open-label outpatient study was conducted at 11 sites in the United States and United Kingdom.Patients with

Biofouling is the accumulation of unwanted material on surfaces submerged or semi submerged over an extended period.This study investigates the antifouling performance of a new bioinspired topography design.A shark riblets inspired topography was designed with Solidworks and CFD simulations were antifouling performance.The study focuses on the flui

Abstract We present a survey of ways in which existing scientific knowledge are included when constructing models with neural networks.The inclusion of domain-knowledge is of special interest not just to constructing scientific assistants, but also, many other areas that involve understanding data using human-machine collaboration.In many such inst

In recent years, the introduction of multiobjective evolutionary algorithms (MOEAs) into the field of endmember extraction (EE) in hyperspectral unmixing has demonstrated a breadth of results that surpass those derived from single-objective-based methodologies.Despite these Vacuum Motor Filter advancements, the adaptation of MOEAs to EE and the att